Objective:To investigate whether orlistat (Alli) reduced risk of death in postmenopausal women with osteoporosis.
Study design:Long-term studies of two different cohorts of postmenopausal women were conducted and compared. The primary outcome was time to death, which was defined as death from any cause during the preceding 5 years. Secondary outcomes included the risk of death from any cause after 6 months, defined as death from any cause during the following 5 years, and the risk of all-cause death.
Results:The study population included 825 women (29.9% male, 71.2% female). The mean age was 66 years, with the majority (n=825, 81.4%) being postmenopausal women. The hazard ratio for death was 1.08 (95% CI, 1.01, 1.13) in the all-cause death cohort (n=825, 81.4%), and all-cause death was significantly associated with low levels of weight (OR=0.96; 95% CI, 0.89, 0.99).
Conclusion:Although the study population was representative of the postmenopausal population, it did not provide any additional information regarding the cardiovascular risk in the postmenopausal women with osteoporosis. The study population should be carefully managed to ensure that they are well educated and appropriately treated for osteoporosis and should be kept at a reasonable risk.
Table 1 Baseline characteristics of postmenopausal women with osteoporosisTable 1:The secondary outcomes of time to death and time to all-cause death after 6 months.
The risk of death after 6 months and time to all-cause death after 3 years
Table 2:The risk of death after 3 years in postmenopausal women with osteoporosis.
Table 3:
The results of the primary outcome were consistent with the results of the secondary outcomes (see Table 2 and Table 3). The results of the secondary outcomes showed that postmenopausal women had reduced rates of all-cause death during the study period: a total of 5.1% in the all-cause death cohort and 4.6% in the non-cause death cohort. This is statistically significant but not consistent with the results of the primary outcome.
The results of the secondary outcomes showed that the hazard ratio for all-cause death was 1.14 (95% CI, 1.00, 1.23). These results are not consistent with the results of the primary outcomes (see Table 2 and Table 3).
The results of the secondary outcomes showed that the hazard ratio for all-cause death was 1.13 (95% CI, 1.01, 1.23).
Table 4:
The results of the secondary outcomes showed that the hazard ratio for all-cause death was 1.17 (95% CI, 1.03, 1.36).
The results of the secondary outcomes showed that the hazard ratio for all-cause death was 1.20 (95% CI, 1.03, 1.42).
Table 5:
The results of the secondary outcomes showed that the hazard ratio for all-cause death was 1.18 (95% CI, 1.03, 1.41).
Healthy weight loss
Top tips for healthy weight loss:
To help you find out if you have a healthy body weight, measure your and waist circumference To lose weight, the energy you take in from food must be less than the energy you use – eat less, move more!
Set yourself realistic goals to achieve a healthy weight. Even small amounts of weight loss can have significant health benefits and can help to set you on a path to a healthier future. Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week
Weight loss can reduce your risk of: heart disease, stroke, type 2 diabetes and some cancers.
It can also reduce the risk of:
High blood pressure Angina (heart condition causing chest pain) High blood cholesterol levels Lower back and joint pain Fertility problems BMI and waist circumference
For most adults:
A BMI between 18.5 and 25 is defined as healthy. A BMI of over 25 is defined as overweight. A BMI of over 30 is defined as obese.
Waist-circumferences for which there is an increased risk and high risk of obesity-related health problems:
Increased risk High risk Men ≥94 cm (37 in) ≥102 cm (40 in) Women ≥80 cm (31.5 in) ≥88 cm (34.5 in)
Sensible weight loss should be seen as an overall lifestyle change which involves eating a healthy balanced diet and doing plenty of physical activity.
Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week. This way, the weight is more likely to stay off. This rate of weight loss is based on using up 600 kcal per day more than you take in. On average, this means consuming no more than 1,400 kcal a day if you are a women, and no more than 1,900 kcal a day if you are a man. The amount of weight you lose will depend on how much weight you need to lose and how active you are.
Further information can be found on the manufacturers
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Orlistat.
The majority of unwanted effects related to the use of Orlistat result from its local action in your digestive system. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Very common (may affect more than 1 in 10 people):
headache abdominal pain/discomfort urgent or increased need to open the bowels flatulence (wind) with or without discharge oily discharge, oily or fatty stools liquid stools low blood sugar levels (experienced by some people with type 2 diabetes) upper respiratory infections flu (influenza)
Irritability, diarrhea or stomach pain high blood pressure And heart disease All other medicines have that common side effects. Orlistat is a lipase type of medicine which means it can cause some side effects not mentioned in this article.
Studies into the possible risk of these symptoms are mixed. There is no proven causal link between Orlistat and any of the following side effects, have been shown in some studies to be not experienced by the person to reduce their risk of any of these symptoms:Experienced people with:
high blood pressure Angina (heart condition causing chest pain) High blood cholesterol levels Lower back and joint pain Fertility problems Abdominal painNausea/vomiting high bowel movements Fast or irregular heartbeat No side effects from Orlistat other than headaches, or decreased bowel movements Diarrhoea (wind) (wind) (wind) (wind) (wind) (orlistat 1g capsules Prices shown on the pharmacy list).
Effects on fertility are not known. The most common are not investigated in any study. Serious but rare (experienced people with diabetes, liver problems, kidney problems, or if no action is taken, or takes action, using Orlistat) affects more than 1 in 100 people.
If you’re new to weight loss treatments and want to learn more about them, we’re here to help.
Tablets like (the brand name for Orlistat) work by reducing the amount of fat your body absorbs. Ordinarily, fats are broken down during the digestion process by enzymes called lipases. Xenical prevents these enzymes from working effectively, limiting how much fat your body is able to absorb. The remaining, undigested fat is then excreted.
In contrast to Xenical, weight loss injections (or pens) work by suppressing your appetite - particularly your appetite for fatty foods. Some weight loss injections also slow the digestion process down, making you feel fuller for longer. They’re simple to use - check out our for more information.
Clinical trials have repeatedly demonstrated the effectiveness of both weight loss tablets and injections, particularly in combination with a healthy diet and lifestyle., participants using lost almost 15% of their body weight over a 15-month period.
Starting your weight loss journey is simple with IQ Doctor. To begin, click on a product and then hit the 'Start Consultation' button. The online consultation process is quick, simple and free; just complete the form and we’ll verify whether the medication is suitable for you or not. If it is, you can then place your order and receive it the very next day.
Add your 12% final weight loss rateAll medication can cause side effects, although the most common side effects may include:
The most common side effects are as follows:
The above list are not exhaustive. If you want to discuss any serious side effects with your doctor, do not delay with your options. If you want to stop taking your medication and are experiencing side effects, talk to your doctor about talking to your doctor. They may suggest that you contact a healthcare provider for medical advice.
It’s general, you can drink alcohol while taking weight loss tablets and it’s often harmless. However, you should avoid drinking too much alcohol as it can cause excessive vomiting, fainting, and even lead to further damage to your liver. Avoiding alcohol can also have a damaging effect on your liver, potentially damaging your kidneys.
Weight loss injections are wider - click on a product and then then then click on a needle. We supply the needle with enough fat to make the injection work best, but not too high. If you don’t have a needle, you can also use a needle. This reduces the risk of infection and ensures that your injection’s results are kept private. We also carry a variety of other medicines, including nutritional supplements, particularly those containing fat, and foods that are high in zinc and vitamins A and D. To ensure your injections’ effectiveness, you’ll need to follow these simple guidelines:
In comparison, 9% to 10% weight loss can be achieved with Xenical. However, the majority of participants (99% of participants) and those for whom oral treatment is planned will achieve 12% and 9% weight loss, respectively, compared to 7% for those for whom dietary advice is taken.
Orlistat is used to treat obesity and help in weight loss. Orlistat is to be used along with a low-calorie diet and regular physical exercise. Obesity is a common condition associated with excessive body fat, which in turn increases the risk of other health problems such as diabetes, high blood pressure, certain cancers, and heart disease. Intake of more calories than you burn by exercise or daily activities results in obesity.
Orlistat contains Orlistat, which works in the small intestine and stomach and prevents the action of enzymes that break down fat, which is absorbed by the body. Orlistat decreases the absorption of fat from the food you eat. Thus, fat passes through the gut and is excreted in the faeces, which makes the body unable to use fat as a source of energy or convert it into fat tissue. Thereby, Orlistat helps in weight loss.
Take Orlistat as prescribed by your doctor. You are advised to take Orlistat for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience soft stools, sudden bowel motions, flatulence (gas) with or without oily spotting, oily or fatty stools, stomach pain, stool incontinence (involuntary leakage of stools), and runny or liquid stools. Most of these side effects of Orlistat do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
If you are allergic to Orlistat or any other medicines, please tell your doctor. Avoid taking Orlistat if you are pregnant or planning for pregnancy, as it may cause fetal harm. It is not known whether Orlistat is excreted in human milk. Therefore, please consult a doctor if you are a breastfeeding woman. Orlistat is not recommended for children below 18 years of age, as the safety and effectiveness were not established. You are advised to take a multivitamin containing fat-soluble vitamins such as A, D, E, and K at bedtime as Orlistat may reduce the absorption of certain vitamins in the body.
The most common side effects of Orlistat are diarrhea, flatulence (gas), loose stools, initude of motion,nausea, and vomiting. If you experience any signs of an allergic reaction, please tell your doctor. Tell your doctor right away if you have dizziness, lightheadedness, fainting, extreme tiredness, a fast heartbeat, fever, muscle weakness, irregular heartbeat, and coma after taking Orlistat. Orlistat should not be used if you are pregnant or breastfeeding. Orlistat may cause breast tenderness and/or enlargement in women. If you experience any changes in breast tissue, please tell your doctor.The most common side effects of Orlistat are diarrhoea, flatulence (gas), oily stools,nausea, and vomiting. Tell your doctor right away if you develop any symptoms as a side effect of Orlistat. Symptoms of a side effect include diarrhea, flatulence (gas), oily stools, nausea, vomiting, and pain in the lower abdomen. If you notice any side effects that are not getting better or worse, please communicate with your doctorive been taking Orlistat for over 6 months and it caused diarrhea, flatulence, and abdominal pain. What do you have to do is give Orlistat a try............................................................................................................................................................................................................................................................................
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